Claim Detail
Treatment/Cause Effect Molecule/Disease In Organ Model Genetic Model Species
in

Tags:
LDLR
Cholesterol Metabolism
PCSK9
Claim Link:
http://researchanalysis.com/TreatmentEffectClaim/fa42f8a63f1778893e3aa1e9b668b8ae

This Claim is supported by the quoted statements and papers below.
Quoted Statement PMID Citation
In three small early-phase trials, REGN727 significantly reduced LDL cholesterol levels. This effect was significant both in healthy volunteers and in subjects with familial or nonfamilial forms of hypercholesterolemia. 22435370 Stein, Evan A., et al. "Effect of a monoclonal antibody to PCSK9 on LDL cholesterol." New England Journal of Medicine 366.12 (2012): 1108-1118.