Claim Detail
Treatment/Cause Effect Molecule/Disease In Organ Model Genetic Model Species
in

Tags:
LDLR
PCSK9
Cholesterol Metabolism
Claim Link:
http://researchanalysis.com/TreatmentEffectClaim/a2cba594fbc0a37e11b1c339946e4aa0

This Claim is supported by the quoted statements and papers below.
Quoted Statement PMID Citation
In three small early-phase trials, REGN727 significantly reduced LDL cholesterol levels. This effect was significant both in healthy volunteers and in subjects with familial or nonfamilial forms of hypercholesterolemia. 22435370 Stein, Evan A., et al. "Effect of a monoclonal antibody to PCSK9 on LDL cholesterol." New England Journal of Medicine 366.12 (2012): 1108-1118.